Backyard Baseball 2001 was the second Backyard Baseball game, and the fourth overall game in the Backyard Sports franchise. It was made for Windows/Macintosh. It was also the second game overall to have pros.
Sammy Sosa appears at the bat, with Mike Piazza catching. Camera closes into them, and Sammy Sosa takes a big swing of the bat and stops to reveal the BBL logo, Then Chipper Jones appears, who picks up a grounder, and throws to second. Stephanie Morgan catches the ball and hits foot on second base to get a sliding Jeff Bagwell (a Houston Astro) out. She throws it to first, covered by Colorado Rockie Larry Walker for the double play. A sweating and panting Dmitri Petrovich who runs by first base, tagged out. Lisa Crocket, who hits a ball that stops and turns into a white circle with the Cleveland Indians logo. Kenny Kawaguchi does the same thing only the ball turns into the Seattle Mariners logo now. Nomar Garciaparra (a Boston Red Sock) hits a Texas Ranger, then Ken Griffey Jr. (a Cincinnati Red), Luanne Lui and Kimmy Eckman, respectively, all take swings. After which more white circles with logos of various MLB teams appear, until all 30 teams appeared. After that, Randy Johnson appears and pitches the ball at the screen, and the Backyard Baseball 2001 logo appears.
Due to similarities with the real teams included in the game, the custom team names Giants and Socks are cut from this installment of the Backyard Baseball series. The name All Stars is also no longer available for the same reason.